大脑中动脉闭塞24小时后,对照组平均ht出血量为0.3 ± 0.4μl,以平均国际标准化比值为1.9 ± 0.5的水平抗凝的小鼠,其平均ht出血量为4.2 ± 1.7μl(与对照组相比p医脉通推荐英文原文摘要
研究者用华法林预处理c57bl/6小鼠(n=59)
stroke. 2011 feb 17. [epub ahead of print]
conclusions
the prevalence of long-term oral anticoagulant therapy is rising. treatment options for patients who have an ischemic stroke大脑中动脉出血症状 under oral anticoagulant therapy are limited, and clinical data on the risk of hemorrhagic transformation (ht) in this condition are scarce. we therefore aimed to establish a mouse model of ischemic stroke occurring during oral anticoagulant therapy to assess the frequency and characteristics of ht.
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结果显示,口服抗凝药治疗时发生卒中会导致所有经抗凝小鼠发生ht,而对照组只有14%的小鼠发生ht未经处理的小鼠(n=32)作为对照组研究者对小鼠的右侧大脑中动脉实施3小时短暂闭塞在第一组小鼠中,研究者用肉眼观察大脑中动脉闭塞24小时后缺血性病变的大小和ht情况在第二组小鼠中,研究者对以不同国际标准化比值抗凝水平处理的小鼠,在大脑中动脉闭塞后不同时间点,采用光度法血红蛋白分析仪进行ht定量分析
oral anticoag大脑中动脉出血如何检查ulant therapy at the onset of ischemia led to ht in all anticoagulated mice, whereas only 14% of the control mice showed ht. mean ht blood volume 24 hours after middle cerebral artery occlusion was 0.3±0.4 μl in controls, 4.2±1.7 μl in mice anticoagulated to a mean international normalized ratio 大脑中动脉出血检查of 1.9±0.5 (p
methods
increased risk of hemorrhagic transformation in ischemic stroke occurring during
目前,长期口服抗凝药治疗的患者比例正在上升对于口服抗凝药治疗时发生缺血性卒中的患者,可选择的治疗方式非常有限;另外,有关这种情况下发生ht的危险度的临床资料也极少为此,研究者建立了口服抗凝药治疗时发生缺血性卒中的小鼠模型,以评估ht的发生率和特点
pmid:
抗凝治疗
c57bl/6 mice (n=59) were pretreated with warfarin. untreated mice (n=32) serve大脑中动脉出血严重吗d as controls. we performed a 3-hour transient filament occlusion of the right middle cerebral artery. in a first set of animals, ischemic lesion size and ht were evaluated macroscopically at 24 hours after middle cerebral artery occlusion. in a second set of mice, quantitative analysis of ht was perfo大脑中动脉出血症状有哪些rmed at different time points after middle cerebral artery occlusion and in animals with different international normalized ratio levels using a photometric hemoglobin assay.
出血危险
文献出处:stroke. 2011 feb 17. [epub ahead of print]
warfarinanticoagulation:an experimental study in mice
期刊影响因子:7.041
results
waltraud pfei大脑中动脉出血检查过程lschifter,daniel spitzer,et.al.
background and purpose
文献标题:increased risk of hemorrhagic transformation in ischemic stroke occurring during warfarin anticoagulation:an experimental study in mice
关键词:
缺血性卒中
1/
we present a mouse model of ischemic stroke occurring during oral anticoagulant therapy. warfarin大脑中动脉出血怎么治疗 pretreatment dramatically increases the risk of ht 24 hours after middle cerebral artery occlusion. reperfusion injury seems to be a critical component in this condition.
近日,德国的一项研究报告,通过建立口服抗凝药治疗时发生缺血性卒中的小鼠模型,研究者发现,华法林预治疗极大增加了大脑中动脉闭塞24小时后的出血性转化(hemorrhagic transformatio, ht)危险,而再灌注损伤似乎是这种情况的重要成因研究报告2月17日在线发表大脑中动脉出血病人需要吃什么东西于美国《stroke》(卒中)杂志
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